A-144 A Cross-Validation Study of Memory and Non-Memory Neuropsychology Measures with Spanish-Speaking Older Adults

Abstract Objective: To evaluate the clinical utility of Spanish versions memory vs. non-memory instruments in a Spanish-speaking sample; specifically, comparative performance for English amnestic MCI (aMCI) and cognitively unimpaired (CU) elders. Method: 255 Non-Hispanic speakers (NH-ES; 157 CU; 98 aMCI) 201 Hispanic (H-SS; 103 were classified using Clinical Dementia Rating Scale validated culturally fair test. ANCOVA procedures used to test differences between four groups across languages adjusting age, sex, education (e.g., Hopkins Verbal Learning Test-HVLT-R; NACC Logical Memory) measures Trail-Making Test A-B, Category Phonemic Fluency). Results: For measures, CU older adults statistically differentiated from aMCI counterparts regardless language. No significant H-SS NH-ES groups’ on HVLT-R story passages immediate/delayed conditions. found indices. Conversely, Bonferroni corrected means (p<.05) revealed that even after adjustment demographic covariates, ES outperformed Trails Category/Phonemic Fluencies. scored better than B. Conclusions: Results indicate experience less bias when employed among different linguistic/cultural cognitive status. In contrast, lower all measures. Factors lead potential bias, particularly are discussed. Trails-B evidenced both MCI, making this measure requires judicious use appropriate norms.